In conclusion, the calcium alginate gel can be used as a possible matrix for IOP electrodes. Although there were slight increases in temperature and pH, chemical and thermal burns were not severe enough to be a concern. Lidocaine transport depended on the alginic acid concentration in the gels. The results revealed that lidocaine was released from calcium alginate gels at concentrations nearly 1.71-fold larger at 5 V, 60 min after AC application than in the case of passive diffusion. Temperature and pH changes were also determined during AC-IOP. We measured the concentration of lidocaine transported from calcium alginate gels with various concentrations of alginic acid using an in vitro experimental cell with square-wave alternating current (AC) application. The purpose of this study is to determine whether calcium alginate gel can be used as a matrix of electrodes for iontophoresis (IOP). Haida, Haruka Ando, Shizuka Ogami, Saori Wakita, Ryo Kohase, Hikaru Saito, Norio Yoshioka, Tomohiko Ikoma, Toshiyuki Tanaka, Junzo Umino, Masahiro Fukayama, HaruhisaĬalcium alginate gel has some unique properties, such as the capability to keep the drugs, bioadhesiveness, safety, and low cost. In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes. The method should be useful for detecting calcium-binding proteins which may trigger neurotransmitter release. In addition this method will detect at least one example from every described class of calcium-binding protein, including lectins and γ-carboxyglutamic acid containing calcium-binding proteins. Their efforts have produced a method which is shorter, has 40-fold greater sensitivity over the previous method, and will detect 'EF hand'-containing calcium-binding proteins in polyacrylamide gels below the 0.5 μg level. The authors refined the method of Schibeci and Martonosi (1980) to enhance detection of calcium-binding proteins in polyacrylamide gels using 45 Ca 2+. International Nuclear Information System (INIS) Improved detection of calcium-binding proteins in polyacrylamide gels
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